Yıl 2017, Cilt 5, Sayı 2, Sayfalar 180 - 192 2017-12-25

Toll benzeri reseptörler

Mehmet ÖZBEK [1] , Mustafa HİTİT [2] , Emel ERGÜN [3] , Feyzullah BEYAZ [4] , Levent ERGÜN [5]

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Doğal bağışıklık polimorfnükleer lökosit, monosit, makrofaj, eozinofil granülosit, mast hücresi ve bazofil granülüsit gibi özelleşmiş hücrelerden ve moleküllerden meydana gelir. Mikrobiyal saldırılara karşı bu hücrelerin bazıları fagositoz yaparak inflamatuvar yanıtı başlatırlar ve organizmanın ilk koruma hattını oluştururlar. Organizmada, bu inflamatuvar yanıta, kalıtımsal olarak aktarılan, patojen tanıyan reseptörlerin (PRR) uyarılması da katkı verir. PRR’ler hem mikrobiyal patojenle ilişkili moleküler kalıpları (PAMP) tanırlar, hem de doku hasarı ve nekrotik hücre ölümü gibi stres faktörleri altında kalan organizmanın kendisi tarafından salgılanan maddelere immun reaksiyon gösterirler. PRR’ler birçok alt tipe ayrılır, bunlar içerisinde en iyi tanımlananlar Toll Benzeri Reseptörlerdir (Toll Like Receptors, TLR). İnsanlarda 10 (TLR1–TLR10), farelerde ise 12 (TLR1–TLR9, TLR11–TLR13) farklı TLR tanımlanmıştır. TLR’ler hücre yüzeyine veya endozom, lizozom, endolizozom gibi hücre içi kompartımanlara lokalize olurlar. Bu moleküller makrofaj ve dendritik hücreler gibi immun sistem hücrelerinin yanında fibroblast ve epitel hücreleri gibi immun sistem dışındaki hücrelerde de eksprese edilebilir. TLR’ler kendileriyle homodimer şeklinde veya koreseptörleri ve aksesuar molekülleriyle heterodimer oluştururlar. Hücre yüzeyinde bulunan TLR’ler öncellikle lipid, lipoprotein, protein gibi mikrobiyal membran bileşenlerini tanırlar. Buna karşın hücre içindeki TLR’ler bakteri ve virüs orjinli nükleik asitleri algılarlar. Ayrıca vücudun kendi nükleik asitlerini tanıyıp otoimmun hastalıklara neden olabilirler.

TLR’ler organizmada hemen hemen bütün sistemlerde immun sistem hücreleri ile birlikte diğer bazı hücrelerde ekspresyon gösterirler. Son yıllarda yapılan çalışmalarla, kanser ve otoimmun hastalıkların patogenezinde TLR’lerin rolü olduğu gösterilmiştir. İlerleyen yıllarda bu reseptörlere karşı kullanılan agonist veya antogonistlerin belirtilen hastalıkların sağaltımında faydalı olabileceği düşünülmektedir.

Doğal bağışıklık, patojen tanıyan reseptörler
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Konular Sağlık Bilimleri
Dergi Bölümü Derleme
Yazarlar

Yazar: Mehmet ÖZBEK
Kurum: Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Histoloji Embriyoloji Anabilim Dalı
Ülke: Turkey


Yazar: Mustafa HİTİT
Kurum: Selçuk Üniversitesi Veteriner Fakültesi Genetik Anabilim Dalı
Ülke: Turkey


Yazar: Emel ERGÜN
Kurum: Ankara Üniversitesi Veteriner Fakültesi Histoloji Embriyoloji Anabilim Dalı
Ülke: Turkey


Yazar: Feyzullah BEYAZ
Kurum: Erciyes Üniversitesi Veteriner Fakültesi Histoloji Embriyoloji Anabilim Dalı
Ülke: Turkey


Yazar: Levent ERGÜN
Kurum: Ankara Üniversitesi Veteriner Fakültesi Histoloji Embriyoloji Anabilim Dalı
Ülke: Turkey


Bibtex @derleme { maeusabed335529, journal = {Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi}, issn = {2148-2837}, address = {Mehmet Akif Ersoy Üniversitesi}, year = {2017}, volume = {5}, pages = {180 - 192}, doi = {10.24998/maeusabed.335529}, title = {Toll benzeri reseptörler}, key = {cite}, author = {HİTİT, Mustafa and ÖZBEK, Mehmet and ERGÜN, Levent and BEYAZ, Feyzullah and ERGÜN, Emel} }
APA ÖZBEK, M , HİTİT, M , ERGÜN, E , BEYAZ, F , ERGÜN, L . (2017). Toll benzeri reseptörler. Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi, 5 (2), 180-192. DOI: 10.24998/maeusabed.335529
MLA ÖZBEK, M , HİTİT, M , ERGÜN, E , BEYAZ, F , ERGÜN, L . "Toll benzeri reseptörler". Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 5 (2017): 180-192 <http://dergipark.gov.tr/maeusabed/issue/33314/335529>
Chicago ÖZBEK, M , HİTİT, M , ERGÜN, E , BEYAZ, F , ERGÜN, L . "Toll benzeri reseptörler". Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 5 (2017): 180-192
RIS TY - JOUR T1 - Toll benzeri reseptörler AU - Mehmet ÖZBEK , Mustafa HİTİT , Emel ERGÜN , Feyzullah BEYAZ , Levent ERGÜN Y1 - 2017 PY - 2017 N1 - doi: 10.24998/maeusabed.335529 DO - 10.24998/maeusabed.335529 T2 - Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi JF - Journal JO - JOR SP - 180 EP - 192 VL - 5 IS - 2 SN - 2148-2837- M3 - doi: 10.24998/maeusabed.335529 UR - http://dx.doi.org/10.24998/maeusabed.335529 Y2 - 2017 ER -
EndNote %0 Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Toll benzeri reseptörler %A Mehmet ÖZBEK , Mustafa HİTİT , Emel ERGÜN , Feyzullah BEYAZ , Levent ERGÜN %T Toll benzeri reseptörler %D 2017 %J Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi %P 2148-2837- %V 5 %N 2 %R doi: 10.24998/maeusabed.335529 %U 10.24998/maeusabed.335529
ISNAD ÖZBEK, Mehmet , HİTİT, Mustafa , ERGÜN, Emel , BEYAZ, Feyzullah , ERGÜN, Levent . "Toll benzeri reseptörler". Mehmet Akif Ersoy Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi 5 / 2 (Aralık 2017): 180-192. http://dx.doi.org/10.24998/maeusabed.335529