Yıl 2018, Cilt 5, Sayı 2, Sayfalar 124 - 129 2018-02-28

Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains

Arzu Irvem [1]

60 115

Objective: The most important problem in the treatment of nosocomial Acinetobacter baumannii (A. baumannii) infections which is increasingly seen in recent years is that almost all strains are resistant to many antibiotics, including carbapenems, and that the extinction of antibiotic options to be used in treatment. This leads the clinicians to new treatment options and suggests the use of combined antibiotics to achieve success in both the treatment of multi-drug-resistant A. baumannii (MDRAB) infections as well as to prevent resistance development. We investigated the in vitro activity of colistin in combination with vancomycin, linezolid or daptomycin against MDRAB to determine whether these combinations would be considered for clinical use. .

Methods: The fractional inhibitory concentration (FIC) index was used to determine the antibiotic combination effects and to evaluate the effect of antibiotic combinations on the bacteria.

Results: MIC values of colistin/vancomycin, colistin/linezolid, and colistin/daptomycin in 10 strains (33.3%) gave similar results. Twenty strains gave different MIC results according to antibiotics. The colistin/daptomycin antagonistic ratio was high when the colistin/vancomycin synergy ratio was high compared to the others.

Conclusion: Antibiotic combinations can be used as an alternative treatment approach in multi-drug resistant A. baumannii infections.

Acinetobacter baumannii, Colistin, Combinations’ effect
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Konular Sağlık Bilimleri
Dergi Bölümü Araştırma Makalesi
Yazarlar

Yazar: Arzu Irvem (Sorumlu Yazar)
E-posta: arzuirvem93@gmail.com
Ülke: Turkey


Bibtex @araştırma makalesi { msd391234, journal = {Medical Science and Discovery}, issn = {2148-6832}, address = {Lycia Press Inc.}, year = {2018}, volume = {5}, pages = {124 - 129}, doi = {10.17546/msd.391234}, title = {Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains}, key = {cite}, author = {Irvem, Arzu} }
APA Irvem, A . (2018). Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains. Medical Science and Discovery, 5 (2), 124-129. DOI: 10.17546/msd.391234
MLA Irvem, A . "Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains". Medical Science and Discovery 5 (2018): 124-129 <http://dergipark.gov.tr/msd/issue/35275/391234>
Chicago Irvem, A . "Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains". Medical Science and Discovery 5 (2018): 124-129
RIS TY - JOUR T1 - Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains AU - Arzu Irvem Y1 - 2018 PY - 2018 N1 - doi: 10.17546/msd.391234 DO - 10.17546/msd.391234 T2 - Medical Science and Discovery JF - Journal JO - JOR SP - 124 EP - 129 VL - 5 IS - 2 SN - 2148-6832-2148-6832 M3 - doi: 10.17546/msd.391234 UR - http://dx.doi.org/10.17546/msd.391234 Y2 - 2018 ER -
EndNote %0 Medical Science and Discovery Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains %A Arzu Irvem %T Colistin-daptomycin, colistin-linezolid, colistin-vancomycin combination effects on colistin in multi-resistant acinetobacter baumannii strains %D 2018 %J Medical Science and Discovery %P 2148-6832-2148-6832 %V 5 %N 2 %R doi: 10.17546/msd.391234 %U 10.17546/msd.391234