Yıl 2016, Cilt 2, Sayı 2, Sayfalar 26 - 35 2016-08-15

The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives
The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derivatives

Feride Akman [1] , Fatih Caglar Celikezen [2] , Aysegul Yazici [3] , Hasan Turkez [4]

929 485

Objective: A series polymer of polystyrene (PS), which doped with potassium biborate (PS-K2B4O7) and 7-hydroxy-4-methylcoumarin (PS-7H4MC) was prepared by solvent casting method.

Material and Methods: All polymeric materials were characterized by Fourier transform infrared spectroscopy (FTIR). Besides, the molecular optimization of polymeric materials was determined using density functional theory (DFT) in ground state. To predict the reactive regions of polymeric materials, the molecular electrostatic potential (MEP) was investigated using theoretical calculations. Cytotoxicity potentials of different concentrations (0 to 320 mg/L) of metabolites on the cultured human blood cells were determined via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) analyses. In addition, chromosomal aberrations (CA) and micronuclei (MN) tests were scored as genetic endpoints.

Results: The FTIR analysis confirmed the presence of polystyrene polymers dopping with potassium biborate and 7-hydroxy-4-methylcoumarin. The MEP maps showed that the negative potential sites were on oxygen atoms.  The results of MTT and LDH analysis showed that PS-K2B4O7 and PS-7H4MC caused significant decreases of cell viability in a clear dose dependent manner.  

Conclusion: cytogenetic results of this study revealed that these polymers neither induced CA nor MN formations. Potassium biborate and 7-hydroxy-4-methylcoumarin doped polystyrene polymers demonstrated ameliorative potential against toxic effects by PS on cultured human peripheral blood lymphocytes in our experimental conditions.

Polystyrene, coumarin; potassium biborate; DFT; MEP; DNA damage, human blood cells
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Konular
Dergi Bölümü Original Articles
Yazarlar

Yazar: Feride Akman

Yazar: Fatih Caglar Celikezen

Yazar: Aysegul Yazici

Yazar: Hasan Turkez

Bibtex @ { nsd260092, journal = {Natural Science and Discovery}, issn = {2149-6307}, eissn = {2149-6307}, address = {Lycia Press Inc.}, year = {2016}, volume = {2}, pages = {26 - 35}, doi = {10.20863/nsd.04460}, title = {The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives}, key = {cite}, author = {Turkez, Hasan and Akman, Feride and Celikezen, Fatih Caglar and Yazici, Aysegul} }
APA Akman, F , Celikezen, F , Yazici, A , Turkez, H . (2016). The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives. Natural Science and Discovery, 2 (2), 26-35. DOI: 10.20863/nsd.04460
MLA Akman, F , Celikezen, F , Yazici, A , Turkez, H . "The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives". Natural Science and Discovery 2 (2016): 26-35 <http://dergipark.gov.tr/nsd/issue/24559/260092>
Chicago Akman, F , Celikezen, F , Yazici, A , Turkez, H . "The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives". Natural Science and Discovery 2 (2016): 26-35
RIS TY - JOUR T1 - The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives AU - Feride Akman , Fatih Caglar Celikezen , Aysegul Yazici , Hasan Turkez Y1 - 2016 PY - 2016 N1 - doi: 10.20863/nsd.04460 DO - 10.20863/nsd.04460 T2 - Natural Science and Discovery JF - Journal JO - JOR SP - 26 EP - 35 VL - 2 IS - 2 SN - 2149-6307-2149-6307 M3 - doi: 10.20863/nsd.04460 UR - http://dx.doi.org/10.20863/nsd.04460 Y2 - 2019 ER -
EndNote %0 Natural Science and Discovery The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives %A Feride Akman , Fatih Caglar Celikezen , Aysegul Yazici , Hasan Turkez %T The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derviatives %D 2016 %J Natural Science and Discovery %P 2149-6307-2149-6307 %V 2 %N 2 %R doi: 10.20863/nsd.04460 %U 10.20863/nsd.04460
ISNAD Akman, Feride , Celikezen, Fatih Caglar , Yazici, Aysegul , Turkez, Hasan . "The Genotoxic and Cytotoxic Effects of Polystyrene Polymers Doped with Boron and Coumarin Derivatives". Natural Science and Discovery 2 / 2 (Ağustos 2016): 26-35. http://dx.doi.org/10.20863/nsd.04460