Yıl 2017, Cilt 21, Sayı 3, Sayfalar 836 - 842 2017-10-24

Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide

Serda KECEL GUNDUZ [1] , Sefa CELIK [2]

387 84

In this current work the conformational properties of the L-Alanyl-L-Glutamine dipeptide which was biological active dipeptide has been investigated by theoretical conformational analysis method using program which is based on Molecular Mechanic calculations in order to determine the structure function relation. The calculations on zwitterionic and neutral form of Ala-Gln which is formed side and main chain torsion angles let us to define their preferable energetically conformers. The side and main chain status of the stable conformations of Ala-Gln were acquired based on the results of the conformational analysis. By using Ramachandran maps, the global conformation, which has the lowest energy of the dipeptide, has been determined. The goal of this work was to explain structure-activity relationship by investigating the bioactive conformation of biological active peptide.
Zwitterionic, Neutral; Ala-Gln; Conformational analysis; DFT
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Konular
Dergi Bölümü Makaleler
Yazarlar

Yazar: Serda KECEL GUNDUZ
E-posta: skecel@istanbul.edu.tr

Yazar: Sefa CELIK
E-posta: scelik@istanbul.edu.tr

Bibtex @ { sdufenbed382233, journal = {Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi}, issn = {}, address = {Süleyman Demirel Üniversitesi}, year = {2017}, volume = {21}, pages = {836 - 842}, doi = {10.19113/sdufbed.02983}, title = {Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide}, key = {cite}, author = {KECEL GUNDUZ, Serda and CELIK, Sefa} }
APA KECEL GUNDUZ, S , CELIK, S . (2017). Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 21 (3), 836-842. Retrieved from http://dergipark.gov.tr/sdufenbed/issue/34610/382233
MLA KECEL GUNDUZ, S , CELIK, S . "Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide". Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21 (2017): 836-842 <http://dergipark.gov.tr/sdufenbed/issue/34610/382233>
Chicago KECEL GUNDUZ, S , CELIK, S . "Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide". Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi 21 (2017): 836-842
RIS TY - JOUR T1 - Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide AU - Serda KECEL GUNDUZ , Sefa CELIK Y1 - 2017 PY - 2017 N1 - DO - T2 - Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi JF - Journal JO - JOR SP - 836 EP - 842 VL - 21 IS - 3 SN - -1308-6529 M3 - UR - Y2 - 2018 ER -
EndNote %0 Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide %A Serda KECEL GUNDUZ , Sefa CELIK %T Molecular Mechanic Studies on the Zwitterionic and Neutral Conformation Stability of Biological Active Peptide %D 2017 %J Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi %P -1308-6529 %V 21 %N 3 %R %U