Year 2012, Volume 42, Issue 3, Pages 403 - 409 2012-03-01

The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer
The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer

İbrahim KAPLAN [1] , Yener AYDIN [2] , Yusuf BİLEN [3] , Fatma GENÇ [4] , Mevlüt Sait KELEŞ [5] , Atila EROĞLU [6]

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Many studies have been conducted to investigate plasma arginine, arginase, and nitric oxide (NO) levels in patients with different types of cancer, and it has been suggested that these might be important factors for patients with cancer. In the present study, plasma arginine, arginase, and nitric oxide levels were evaluated in patients with esophageal cancer. Materials and methods: A total of 100 patients (51 females and 49 males) diagnosed with esophageal cancer but not yet operated on were included in the study. The mean age of the study population was 62.03 ± 12.4 years. Patients treated with radiotherapy or chemotherapy were excluded. The control group included 80 subjects (38 females and 42 males) with a mean age of 57 ± 12.4 years. Plasma arginine, NO levels, and arginase activity were measured. High-performance liquid chromatography, Griess reactions, and modified Geyer and Dabich methods were used to detect the arginine levels, NO levels, and arginase activity. Results: In patients with esophageal cancer, plasma arginine concentrations were significantly lower and NO levels and arginase activity were significantly higher than in the control groups (P < 0.0001, P < 0.0001, and P = 0.005, respectively). The sensitivity of arginase and NO were estimated at 87% and 89%, with respective specificities of 65% and 66%. Between the patients with and without distant organ metastasis, there were no significant differences in arginine/NO levels and arginase activity (P > 0.05). Similarly, there were no significant differences in these parameters between the patients with squamous cell carcinoma and adenocarcinoma (P > 0.05). Conclusion: The results demonstrate that plasma NO levels and arginase activity may be used as markers for the diagnosis of esophageal cancer. However, larger and more comprehensive studies are needed.
Many studies have been conducted to investigate plasma arginine, arginase, and nitric oxide (NO) levels in patients with different types of cancer, and it has been suggested that these might be important factors for patients with cancer. In the present study, plasma arginine, arginase, and nitric oxide levels were evaluated in patients with esophageal cancer. Materials and methods: A total of 100 patients (51 females and 49 males) diagnosed with esophageal cancer but not yet operated on were included in the study. The mean age of the study population was 62.03 ± 12.4 years. Patients treated with radiotherapy or chemotherapy were excluded. The control group included 80 subjects (38 females and 42 males) with a mean age of 57 ± 12.4 years. Plasma arginine, NO levels, and arginase activity were measured. High-performance liquid chromatography, Griess reactions, and modified Geyer and Dabich methods were used to detect the arginine levels, NO levels, and arginase activity. Results: In patients with esophageal cancer, plasma arginine concentrations were significantly lower and NO levels and arginase activity were significantly higher than in the control groups (P < 0.0001, P < 0.0001, and P = 0.005, respectively). The sensitivity of arginase and NO were estimated at 87% and 89%, with respective specificities of 65% and 66%. Between the patients with and without distant organ metastasis, there were no significant differences in arginine/NO levels and arginase activity (P > 0.05). Similarly, there were no significant differences in these parameters between the patients with squamous cell carcinoma and adenocarcinoma (P > 0.05). Conclusion: The results demonstrate that plasma NO levels and arginase activity may be used as markers for the diagnosis of esophageal cancer. However, larger and more comprehensive studies are needed.
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Primary Language tr
Subjects
Journal Section Articles
Authors

Author: İbrahim KAPLAN

Author: Yener AYDIN

Author: Yusuf BİLEN

Author: Fatma GENÇ

Author: Mevlüt Sait KELEŞ

Author: Atila EROĞLU

Bibtex @ { tbtkmedical147102, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {TUBITAK}, year = {2012}, volume = {42}, pages = {403 - 409}, doi = {}, title = {The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer}, key = {cite}, author = {KAPLAN, İbrahim and AYDIN, Yener and BİLEN, Yusuf and GENÇ, Fatma and KELEŞ, Mevlüt Sait and EROĞLU, Atila} }
APA KAPLAN, İ , AYDIN, Y , BİLEN, Y , GENÇ, F , KELEŞ, M , EROĞLU, A . (2012). The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer. Turkish Journal of Medical Sciences, 42 (3), 403-409. Retrieved from http://dergipark.gov.tr/tbtkmedical/issue/12298/147102
MLA KAPLAN, İ , AYDIN, Y , BİLEN, Y , GENÇ, F , KELEŞ, M , EROĞLU, A . "The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer". Turkish Journal of Medical Sciences 42 (2012): 403-409 <http://dergipark.gov.tr/tbtkmedical/issue/12298/147102>
Chicago KAPLAN, İ , AYDIN, Y , BİLEN, Y , GENÇ, F , KELEŞ, M , EROĞLU, A . "The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer". Turkish Journal of Medical Sciences 42 (2012): 403-409
RIS TY - JOUR T1 - The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer AU - İbrahim KAPLAN , Yener AYDIN , Yusuf BİLEN , Fatma GENÇ , Mevlüt Sait KELEŞ , Atila EROĞLU Y1 - 2012 PY - 2012 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 403 EP - 409 VL - 42 IS - 3 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer %A İbrahim KAPLAN , Yener AYDIN , Yusuf BİLEN , Fatma GENÇ , Mevlüt Sait KELEŞ , Atila EROĞLU %T The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer %D 2012 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 42 %N 3 %R %U
ISNAD KAPLAN, İbrahim , AYDIN, Yener , BİLEN, Yusuf , GENÇ, Fatma , KELEŞ, Mevlüt Sait , EROĞLU, Atila . "The evaluation of plasma arginine, arginase, and nitric oxide levels in patients with esophageal cancer". Turkish Journal of Medical Sciences 42 / 3 (March 2012): 403-409.