Year 2015, Volume 45, Issue 6, Pages 1234 - 1242 2015-12-04

The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA
The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA

ZUHAL KANDEMİR [1] , AYŞEGÜL ŞENTÜRK [2] , ELİF ÖZDEMİR [3] , NİLÜFER YILDIRIM [4] , HATİCE CANAN HASANOĞLU [5] , MUTLAY KESKİN [6] , ŞEYDA TÜRKÖLMEZ [7]

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Background/aim: We aimed to define the optimal SUVmax cut-off value in determination of mediastinal-hilar lymph node metastasis, by comparing positive PET/CT results with the results of endobronchial ultrasound guided transbronchial needle aspiration biopsy (EBUS-TBNA). Materials and methods: Thirty-one patients with malignancy whose PET/CT imaging revealed a hypermetabolic mediastinal and/or hilar lymph node and who had undergone EBUS-TBNA were evaluated retrospectively. Histopathology was regarded as the gold standard. The diagnostic role of PET/CT in mediastinal/hilar lymph node metastasis was investigated and compared with the results of contrast-enhanced CT. Results: When a SUVmax value of 2.5 was used, the sensitivity, positive predictive value (PPV), and diagnostic accuracy of the PET/CT were 100%, 65.4%, and 65.4% respectively. In the ROC analysis, the SUVmax cut-off value with the highest diagnostic accuracy (75%) was calculated as 6.3, and when this value was considered, the sensitivity, specificity, PPV, negative predictive value, and diagnostic accuracy of the PET/CT were determined as 70.6%, 83.3%, 88.9%, 60%, and 75% respectively (AUC: 0.779). The sensitivity, PPV, and diagnostic accuracy of the thorax CT were calculated as 91.1%, 72%, and 71.1%, respectively. Conclusion: When determining mediastinal-hilar lymph node metastasis via PET/CT, although a SUVmax cut-off value of 6.3 increases specificity and diagnostic accuracy, we think that a SUVmax cut-off value of 2.5 and above give more optimal results in routine practice.
Background/aim: We aimed to define the optimal SUVmax cut-off value in determination of mediastinal-hilar lymph node metastasis, by comparing positive PET/CT results with the results of endobronchial ultrasound guided transbronchial needle aspiration biopsy (EBUS-TBNA). Materials and methods: Thirty-one patients with malignancy whose PET/CT imaging revealed a hypermetabolic mediastinal and/or hilar lymph node and who had undergone EBUS-TBNA were evaluated retrospectively. Histopathology was regarded as the gold standard. The diagnostic role of PET/CT in mediastinal/hilar lymph node metastasis was investigated and compared with the results of contrast-enhanced CT. Results: When a SUVmax value of 2.5 was used, the sensitivity, positive predictive value (PPV), and diagnostic accuracy of the PET/CT were 100%, 65.4%, and 65.4% respectively. In the ROC analysis, the SUVmax cut-off value with the highest diagnostic accuracy (75%) was calculated as 6.3, and when this value was considered, the sensitivity, specificity, PPV, negative predictive value, and diagnostic accuracy of the PET/CT were determined as 70.6%, 83.3%, 88.9%, 60%, and 75% respectively (AUC: 0.779). The sensitivity, PPV, and diagnostic accuracy of the thorax CT were calculated as 91.1%, 72%, and 71.1%, respectively. Conclusion: When determining mediastinal-hilar lymph node metastasis via PET/CT, although a SUVmax cut-off value of 6.3 increases specificity and diagnostic accuracy, we think that a SUVmax cut-off value of 2.5 and above give more optimal results in routine practice.
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Primary Language tr
Subjects
Journal Section Articles
Authors

Author: ZUHAL KANDEMİR

Author: AYŞEGÜL ŞENTÜRK

Author: ELİF ÖZDEMİR

Author: NİLÜFER YILDIRIM

Author: HATİCE CANAN HASANOĞLU

Author: MUTLAY KESKİN

Author: ŞEYDA TÜRKÖLMEZ

Bibtex @ { tbtkmedical149005, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {TUBITAK}, year = {2015}, volume = {45}, pages = {1234 - 1242}, doi = {}, title = {The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA}, key = {cite}, author = {KANDEMİR, ZUHAL and ŞENTÜRK, AYŞEGÜL and ÖZDEMİR, ELİF and YILDIRIM, NİLÜFER and HASANOĞLU, HATİCE CANAN and KESKİN, MUTLAY and TÜRKÖLMEZ, ŞEYDA} }
APA KANDEMİR, Z , ŞENTÜRK, A , ÖZDEMİR, E , YILDIRIM, N , HASANOĞLU, H , KESKİN, M , TÜRKÖLMEZ, Ş . (2015). The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA. Turkish Journal of Medical Sciences, 45 (6), 1234-1242. Retrieved from http://dergipark.gov.tr/tbtkmedical/issue/12391/149005
MLA KANDEMİR, Z , ŞENTÜRK, A , ÖZDEMİR, E , YILDIRIM, N , HASANOĞLU, H , KESKİN, M , TÜRKÖLMEZ, Ş . "The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA". Turkish Journal of Medical Sciences 45 (2015): 1234-1242 <http://dergipark.gov.tr/tbtkmedical/issue/12391/149005>
Chicago KANDEMİR, Z , ŞENTÜRK, A , ÖZDEMİR, E , YILDIRIM, N , HASANOĞLU, H , KESKİN, M , TÜRKÖLMEZ, Ş . "The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA". Turkish Journal of Medical Sciences 45 (2015): 1234-1242
RIS TY - JOUR T1 - The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA AU - ZUHAL KANDEMİR , AYŞEGÜL ŞENTÜRK , ELİF ÖZDEMİR , NİLÜFER YILDIRIM , HATİCE CANAN HASANOĞLU , MUTLAY KESKİN , ŞEYDA TÜRKÖLMEZ Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1234 EP - 1242 VL - 45 IS - 6 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA %A ZUHAL KANDEMİR , AYŞEGÜL ŞENTÜRK , ELİF ÖZDEMİR , NİLÜFER YILDIRIM , HATİCE CANAN HASANOĞLU , MUTLAY KESKİN , ŞEYDA TÜRKÖLMEZ %T The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 6 %R %U
ISNAD KANDEMİR, ZUHAL , ŞENTÜRK, AYŞEGÜL , ÖZDEMİR, ELİF , YILDIRIM, NİLÜFER , HASANOĞLU, HATİCE CANAN , KESKİN, MUTLAY , TÜRKÖLMEZ, ŞEYDA . "The evaluation of hypermetabolic mediastinal?hilar lymph nodes determined byPET/CT in pulmonary and extrapulmonary malignancies: correlation with EBUS-TBNA". Turkish Journal of Medical Sciences 45 / 6 (December 2015): 1234-1242.