Year 2015, Volume 45, Issue 6, Pages 1403 - 1412 2015-12-04

Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats
Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats

ZERRİN SEZGİN BAYINDIR [1] , ARZU BEŞİKCİ [2] , NİLÜFER YÜKSEL [3]

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Background/aim: The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats. Materials and methods: Paclitaxel-loaded Span 40 niosomes were prepared using the thin-film method. An HPLC method was developed and validated for paclitaxel determination in rat plasma and tissues. Results: The area under the curve value of the niosome-recipient group (3.22 ± 0.255 μg h/mL) was significantly higher compared to that of the Taxol group (0.725 ± 0.163 μg h/mL). The mean residence time and the elimination half-life of paclitaxel were 1.66 ± 0.133 h and 1.15 ± 0.085 h for Taxol administration, respectively. The elimination half-life (7.63 ± 0.380 h) and the mean residence time (11.0 ± 0.6 h) of paclitaxel were significantly increased, and a pronounced delay was observed in general excretion of paclitaxel from plasma (0.0925 ± 0.00490 h-1) after niosomal administration. The spleen was the main tissue that accumulated paclitaxel from both niosomes and Taxol. Conclusion: The findings of this study show that niosomal formulation might be a useful drug delivery system for intravenous administration of paclitaxel.
Background/aim: The purpose of this study was to investigate and compare the pharmacokinetic behavior and tissue distribution of paclitaxel, delivered as commercial preparation Taxol or through Span 40 niosomes, after intravenous injection to rats. Materials and methods: Paclitaxel-loaded Span 40 niosomes were prepared using the thin-film method. An HPLC method was developed and validated for paclitaxel determination in rat plasma and tissues. Results: The area under the curve value of the niosome-recipient group (3.22 ± 0.255 μg h/mL) was significantly higher compared to that of the Taxol group (0.725 ± 0.163 μg h/mL). The mean residence time and the elimination half-life of paclitaxel were 1.66 ± 0.133 h and 1.15 ± 0.085 h for Taxol administration, respectively. The elimination half-life (7.63 ± 0.380 h) and the mean residence time (11.0 ± 0.6 h) of paclitaxel were significantly increased, and a pronounced delay was observed in general excretion of paclitaxel from plasma (0.0925 ± 0.00490 h-1) after niosomal administration. The spleen was the main tissue that accumulated paclitaxel from both niosomes and Taxol. Conclusion: The findings of this study show that niosomal formulation might be a useful drug delivery system for intravenous administration of paclitaxel.
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Author: ZERRİN SEZGİN BAYINDIR

Author: ARZU BEŞİKCİ

Author: NİLÜFER YÜKSEL

Bibtex @ { tbtkmedical149030, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {TUBITAK}, year = {2015}, volume = {45}, pages = {1403 - 1412}, doi = {}, title = {Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats}, key = {cite}, author = {BAYINDIR, ZERRİN SEZGİN and BEŞİKCİ, ARZU and YÜKSEL, NİLÜFER} }
APA BAYINDIR, Z , BEŞİKCİ, A , YÜKSEL, N . (2015). Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats. Turkish Journal of Medical Sciences, 45 (6), 1403-1412. Retrieved from http://dergipark.gov.tr/tbtkmedical/issue/12391/149030
MLA BAYINDIR, Z , BEŞİKCİ, A , YÜKSEL, N . "Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats". Turkish Journal of Medical Sciences 45 (2015): 1403-1412 <http://dergipark.gov.tr/tbtkmedical/issue/12391/149030>
Chicago BAYINDIR, Z , BEŞİKCİ, A , YÜKSEL, N . "Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats". Turkish Journal of Medical Sciences 45 (2015): 1403-1412
RIS TY - JOUR T1 - Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats AU - ZERRİN SEZGİN BAYINDIR , ARZU BEŞİKCİ , NİLÜFER YÜKSEL Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1403 EP - 1412 VL - 45 IS - 6 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2019 ER -
EndNote %0 Turkish Journal of Medical Sciences Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats %A ZERRİN SEZGİN BAYINDIR , ARZU BEŞİKCİ , NİLÜFER YÜKSEL %T Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 6 %R %U
ISNAD BAYINDIR, ZERRİN SEZGİN , BEŞİKCİ, ARZU , YÜKSEL, NİLÜFER . "Paclitaxel-loaded niosomes for intravenous administration: pharmacokineticsand tissue distribution in rats". Turkish Journal of Medical Sciences 45 / 6 (December 2015): 1403-1412.