Yıl 2016, Cilt 19, Sayı 4, Sayfalar 155 - 158 2018-05-26

HISTOLOGIC EVALUATION OF ATYPICAL SQUAMOUS CELLS-CANNOT EXCLUDE HIGH-GRADE SQUAMOUS INTRAEPITHELIAL LESION (ASC-H) CYTOLOGY
ASC-H (YÜKSEK DERECELİ LEZYONUN DIŞLANAMADIĞI ATİPİK HÜCRE) SİTOLOJİ SONUÇLARININ HİSTOLOJİK OLARAK DEĞERLENDİRİLMESİ

Aykut Tuncer [1] , Ali Ayhan [2]

17 20

Aim: To estimate predictors for histological diagnosis of cervical intraepithelial neoplasia of grade ≥2 (≥CIN 2) in patients with atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H) on cervical cytology. Materials and Methods: We retrospectively reviewed the patients with ASC-H who had undergone colposcopic biopsy between the years 2007-2015. Age, parity, menapousal status, marriage status, smoking habitus, high risk Human Papilloma Virus (hrHPV) status were analized with forward likelihood ratio method and significance was set at p <0.05. Results: 93 patients with ASC-H were undergone colposcopy-guided bioopsy. Mean age of the patients was 39.37±1.03 (20-63). HPV test was performed to 30 patients and 10 (33.3 % ) were HR-HPV positive (+). Histologic diagnosis were reported as normal in 44 (47.3 % ), CIN 1 in 10 (10.8 % ), CIN 2 in 24 (25.8 % ), CIN 3 in 12 (12.9 % ) and cervical cancer in 3 (3.2 % ) patients. Mean age of ≥ CIN 2 patients were 41.13±10.45 compared with 36.92±8.61 for ≤ CIN 1 patients (p=0.042). 9 of 10 (90 % ) HR-HPV (+) patients and 18 of 32 (56.2 % ) smokers had ≥ CIN 2 lesions whereas two of 20 (10 % ) HR-HPV negative (-) patients and 18 of 55 (32.7 % ) non-smokers had ≥ CIN 2 lesions (p values were, <0.001 and 0.03 for HR-HPV and smoking status, respectively). According to regression analysis (+) HR-HPV test was the only predictor [vs. (-) HR-HPVtest; OR 6.351; 95% CI 3.673–8.947, p=0.014]. Conclusion: Colposcopic evaluation, biopsy and histological diagnosis should be performed carefully for ASC-H patients, especially if they are HR-HPV positive.

Amaç: Servikal sitolojisinde yüksek dereceli squamöz intraepitelial lezyon dışlanamayan atipik skuamöz hücreler (ASC-H) saptanan hastalarda histolojide servikal intraepitelial lezyon grade ≥2 (≥ CIN 2) tanısının belirleyicilerini ortaya koymaktır. Material ve Metod: 2007- 2015 yıllarında servikal sitoloji sonucu ASC-H olup kolposkopi ile değerlendirilen olgular çalışmaya dahil edildi. Hastaların yaşı, paritesi, menapoz durumu, medeni hali, sigara kullanımı, yüksek riskli human papilloma virüs taşıyıcılığı (hrHPV) ileri doğru regresyon methodu ile analiz edildi. Anlamlılık p <0.05 değerinde hesaplandı. Bulgular: Sitoloji sonucu ASC-H olan 93 hastaya kolposkopik biyopsi yapıldı ve çalışma kapsamında değerlendirildi. Hastaların ortalama yaşı 39.37±1.03 (20-63) olup 32 hasta (% 36.8) sigara kullanmaktaydı. HPV testi 30 hastada yapılmıştı ve 10 hastada (% 33.3) hrHPV tespit edildi. Kolposkopik histoloji tanısı sonucu 44 (% 47.3) hastada normal, 10 (% 10.8), hastada CIN 1, 24 (% 25.8) hastada CIN 2, 12 (% 12.9) hastada CIN 3, 3 hastada da (% 3.2) serviks kanseri tespit edildi. ≥ CIN 2 saptanan hastaların ortalama yaşı (41.13±10.45), ≤ CIN 1 saptanan hastaların ortalama yaşı (36.92±8.61)’ndan yüksekti (p=0.042). HrHPV (+) olan 10 hastadan 9’unda (% 90), buna karşın hrHPV (-) olan 20 hastadan 2’sinde (% 10) ≥ CIN 2 lezyonu olup (p <0.001), sigara kullanan 32 hastadan 18’inde (% 56.2), buna karşın sigara kullanmayan 55 hastadan 18’inde (% 32.7) ≥CIN 2 lezyon tespit edildi (p <0.03). Regresyon analiz sonucucuna göre tek belirleyici (+) hrHPV test olarak bulundu [vs. (-) hrHPVtest; OR 6.351; 95% CI 3.673–8.947, p=0.014]. Sonuç: HPV + olan ASC-H sitolojisine sahip kadınlarda ≥ CIN 2 lezyon riski yüksek olduğundan kolposkopik muayene, biyopsi ve patolojik değerlendirme dikkatli yapılmalıdır


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Birincil Dil tr
Konular Cerrahi Tıp Bilimleri
Dergi Bölümü Araştırma Makalesi
Yazarlar

Yazar: Aykut Tuncer (Sorumlu Yazar)
E-posta: aykuttuncer@hotmail.com

Yazar: Ali Ayhan
E-posta: aliayhan@baskent.edu.tr

Bibtex @araştırma makalesi { trsgo426146, journal = {Türk Jinekolojik Onkoloji Dergisi}, issn = {2148-5372}, address = {Türk Jinekolojik Onkoloji Derneği}, year = {2018}, volume = {19}, pages = {155 - 158}, doi = {}, title = {ASC-H (YÜKSEK DERECELİ LEZYONUN DIŞLANAMADIĞI ATİPİK HÜCRE) SİTOLOJİ SONUÇLARININ HİSTOLOJİK OLARAK DEĞERLENDİRİLMESİ}, key = {cite}, author = {Tuncer, Aykut and Ayhan, Ali} }
APA Tuncer, A , Ayhan, A . (2018). ASC-H (YÜKSEK DERECELİ LEZYONUN DIŞLANAMADIĞI ATİPİK HÜCRE) SİTOLOJİ SONUÇLARININ HİSTOLOJİK OLARAK DEĞERLENDİRİLMESİ. Türk Jinekolojik Onkoloji Dergisi, 19 (4), 155-158. Retrieved from http://dergipark.gov.tr/trsgo/issue/37065/426146
MLA Tuncer, A , Ayhan, A . "ASC-H (YÜKSEK DERECELİ LEZYONUN DIŞLANAMADIĞI ATİPİK HÜCRE) SİTOLOJİ SONUÇLARININ HİSTOLOJİK OLARAK DEĞERLENDİRİLMESİ". Türk Jinekolojik Onkoloji Dergisi 19 (2018): 155-158 <http://dergipark.gov.tr/trsgo/issue/37065/426146>
Chicago Tuncer, A , Ayhan, A . "ASC-H (YÜKSEK DERECELİ LEZYONUN DIŞLANAMADIĞI ATİPİK HÜCRE) SİTOLOJİ SONUÇLARININ HİSTOLOJİK OLARAK DEĞERLENDİRİLMESİ". Türk Jinekolojik Onkoloji Dergisi 19 (2018): 155-158
RIS TY - JOUR T1 - ASC-H (YÜKSEK DERECELİ LEZYONUN DIŞLANAMADIĞI ATİPİK HÜCRE) SİTOLOJİ SONUÇLARININ HİSTOLOJİK OLARAK DEĞERLENDİRİLMESİ AU - Aykut Tuncer , Ali Ayhan Y1 - 2018 PY - 2018 N1 - DO - T2 - Türk Jinekolojik Onkoloji Dergisi JF - Journal JO - JOR SP - 155 EP - 158 VL - 19 IS - 4 SN - 2148-5372- M3 - UR - Y2 - 2018 ER -
EndNote %0 Türk Jinekolojik Onkoloji Dergisi ASC-H (YÜKSEK DERECELİ LEZYONUN DIŞLANAMADIĞI ATİPİK HÜCRE) SİTOLOJİ SONUÇLARININ HİSTOLOJİK OLARAK DEĞERLENDİRİLMESİ %A Aykut Tuncer , Ali Ayhan %T ASC-H (YÜKSEK DERECELİ LEZYONUN DIŞLANAMADIĞI ATİPİK HÜCRE) SİTOLOJİ SONUÇLARININ HİSTOLOJİK OLARAK DEĞERLENDİRİLMESİ %D 2018 %J Türk Jinekolojik Onkoloji Dergisi %P 2148-5372- %V 19 %N 4 %R %U