Effects of Occupational Toluene and Trichloroethylene Exposure on Liver Enzymes

Ceylan Bal [1] , Murat Büyükşekerci [2] , Erol Rauf Ağış [3] , Mujgan Ercan [4] , Meşide Gündüzöz [5] , Mehmet Köş [6] , Asım Hocaoğlu [7] , Ömer Hınç Yılmaz [8]

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Toluene and trichlorethylene are organic solvents which are widely used in industrial settings .Occupational exposure of these solvents may induce hepatic injury. In this study we determined the hepatic enzymes alanine transaminase (ALT) and aspartate transaminase (AST) of the workers who are occupationally exposed to toluene (n=152), trichloroethylene (n=125) , or both (n=77); group 1, group 2 and group 3 respectively. Comparison with a control group (n=158) whom are not occupationally exposed to any organic solvent was done.

Regarding AST and ALT we observed a significant increase in solvent exposed (toluen, triccloroethylene(TCE) , toluen and TCE) groups when compared to non-exposed control group (p < 0.001). The median values of AST and ALT for solvent exposed groups did not exceed reference range. ALT levels were above reference levels in 5.3% of group 1, 7.2% of group 2 and 5.2% of group 3 . Also AST levels were above reference levels in 5.9% of Group 1, 4% of Group 2 and 3,9 % of Group 3. In all of the exposed groups, the percentage of above the reference level of both enzymes, were significantly higher than the control group. None of the controls had above the threshold enzyme levels. Exposed groups all had a ratio of ALT to AST (ALT/AST) higher than 1; 1.14, 1.2, 1.09 for group 1, group 2, and group 3 respectively.

According to our results toluene and TCE does not cause acute hepatotoxicity but some elevation of ALT and AST is present. ALT and AST of occupationally solvent exposed workers should be routinely monitored and necessary precautions should be taken.



alanine transaminase; aspartate transaminase; toluene; trichloroethylene; occupational exposure
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Konular Dahili Tıp Bilimleri
Dergi Bölümü Articles
Yazarlar

Yazar: Ceylan Bal

Yazar: Murat Büyükşekerci

Yazar: Erol Rauf Ağış

Yazar: Mujgan Ercan

Yazar: Meşide Gündüzöz

Yazar: Mehmet Köş

Yazar: Asım Hocaoğlu

Yazar: Ömer Hınç Yılmaz

Bibtex @araştırma makalesi { turjoem284606, journal = {The Turkish Journal Of Occupational / Environmental Medicine and Safety}, issn = {2149-4711}, eissn = {2149-4711}, address = {Engin TUTKUN}, year = {}, volume = {1}, pages = {1 - 10}, doi = {}, title = {Effects of Occupational Toluene and Trichloroethylene Exposure on Liver Enzymes}, key = {cite}, author = {Yılmaz, Ömer Hınç and Büyükşekerci, Murat and Ercan, Mujgan and Gündüzöz, Meşide and Köş, Mehmet and Ağış, Erol Rauf and Bal, Ceylan and Hocaoğlu, Asım} }
APA Bal, C , Büyükşekerci, M , Ağış, E , Ercan, M , Gündüzöz, M , Köş, M , Hocaoğlu, A , Yılmaz, Ö . (). Effects of Occupational Toluene and Trichloroethylene Exposure on Liver Enzymes. The Turkish Journal Of Occupational / Environmental Medicine and Safety, 1 (1), 1-10. Retrieved from http://dergipark.gov.tr/turjoem/issue/27020/284606
MLA Bal, C , Büyükşekerci, M , Ağış, E , Ercan, M , Gündüzöz, M , Köş, M , Hocaoğlu, A , Yılmaz, Ö . "Effects of Occupational Toluene and Trichloroethylene Exposure on Liver Enzymes". The Turkish Journal Of Occupational / Environmental Medicine and Safety 1 (): 1-10 <http://dergipark.gov.tr/turjoem/issue/27020/284606>
Chicago Bal, C , Büyükşekerci, M , Ağış, E , Ercan, M , Gündüzöz, M , Köş, M , Hocaoğlu, A , Yılmaz, Ö . "Effects of Occupational Toluene and Trichloroethylene Exposure on Liver Enzymes". The Turkish Journal Of Occupational / Environmental Medicine and Safety 1 (): 1-10
RIS TY - JOUR T1 - Effects of Occupational Toluene and Trichloroethylene Exposure on Liver Enzymes AU - Ceylan Bal , Murat Büyükşekerci , Erol Rauf Ağış , Mujgan Ercan , Meşide Gündüzöz , Mehmet Köş , Asım Hocaoğlu , Ömer Hınç Yılmaz Y1 - 2018 PY - 2018 N1 - DO - T2 - The Turkish Journal Of Occupational / Environmental Medicine and Safety JF - Journal JO - JOR SP - 1 EP - 10 VL - 1 IS - 1 SN - 2149-4711-2149-4711 M3 - UR - Y2 - 2018 ER -
EndNote %0 The Turkish Journal Of Occupational / Environmental Medicine and Safety Effects of Occupational Toluene and Trichloroethylene Exposure on Liver Enzymes %A Ceylan Bal , Murat Büyükşekerci , Erol Rauf Ağış , Mujgan Ercan , Meşide Gündüzöz , Mehmet Köş , Asım Hocaoğlu , Ömer Hınç Yılmaz %T Effects of Occupational Toluene and Trichloroethylene Exposure on Liver Enzymes %D 2018 %J The Turkish Journal Of Occupational / Environmental Medicine and Safety %P 2149-4711-2149-4711 %V 1 %N 1 %R %U
ISNAD Bal, Ceylan , Büyükşekerci, Murat , Ağış, Erol Rauf , Ercan, Mujgan , Gündüzöz, Meşide , Köş, Mehmet , Hocaoğlu, Asım , Yılmaz, Ömer Hınç . "Effects of Occupational Toluene and Trichloroethylene Exposure on Liver Enzymes". The Turkish Journal Of Occupational / Environmental Medicine and Safety 1 / 1 1-10.