Yıl 2017, Cilt 22, Sayı 3, Sayfalar 127 - 144 2017-12-28

Production and Crosslinking of Polysaccharide Based Nanofibrous Mat for Biomedical Applications
BİYOMEDİKAL UYGULAMALAR İÇİN POLİSAKKARİT ESASLI NANOLİFLİ YÜZEY ÜRETİMİ VE ÇAPRAZ BAĞLANMASI

Şerife ŞAFAK [1] , Esra KARACA [2]

90 126

Polysaccharide based polymers are widely used in biomedical applications. In this study, nanofibrous mat was produced from hyaluronic acid, carboxymethyl cellulose and sodium alginate polysaccharide polymers via electrospinning method. Resultant nanofibrous mat was crosslinked with 1-etil-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide solution to develop its water resistance. Before and after the crosslinking process, nanofibrous mat was characterized by scanning electron microscope, fourier transform infrared spectrometry, atomic force microscope, BET analysis and water resistance test. The results indicated that the nanofibrous mat was become resistant to water without any deformation of nanofibrous structure with the crosslinking application.

Polisakkarit esaslı polimerler, biyomedikal uygulamalarda yaygın olarak kullanılmaktadır. Bu çalışmada; polisakkarit hyaluronik asit, karboksimetil selüloz ve sodyum alginat polimerleri kullanılarak elektro çekim yöntemiyle nanolifli yüzey üretimi gerçekleştirilmiştir. Üretilen nanolifli yüzeye, suya dayanımını geliştirmek amacıyla, 1-etil-3-(3-dimetilaminopropil) karbodiimid hidroklorit ve N-hidroksisülfosüksinimit karışımı ile çapraz bağlama işlemi uygulanmıştır. Nanolifli yüzey, çapraz bağlama işlemi öncesi ve sonrasında, taramalı elektron mikroskobu, fourier transform infrared spektrometresi, atomik kuvvet mikroskobu, BET analizi ve suya dayanım testi ile karakterize edilmiştir. Sonuçlar; çapraz bağlama işlemi ile lifli yapının deformasyona uğramadan nanolifli yüzeyin suya dayanıklı hale geldiğini göstermiştir.

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Konular Mühendislik ve Temel Bilimler
Dergi Bölümü Araştırma Makaleleri
Yazarlar

Yazar: Şerife ŞAFAK
E-posta: ekaraca@uludag.edu.tr
Kurum: Namık Kemal Üniversitesi Çorlu Mühendislik Fakültesi
Ülke: Turkey


Yazar: Esra KARACA
E-posta: ekaraca@uludag.edu.tr
Kurum: Uludağ Üniversitesi Mühendislik Fakültesi
Ülke: Turkey


Bibtex @araştırma makalesi { uumfd309657, journal = {Uludağ University Journal of The Faculty of Engineering}, issn = {2148-4147}, address = {Uludağ Üniversitesi}, year = {2017}, volume = {22}, pages = {127 - 144}, doi = {10.17482/uumfd.309657}, title = {BİYOMEDİKAL UYGULAMALAR İÇİN POLİSAKKARİT ESASLI NANOLİFLİ YÜZEY ÜRETİMİ VE ÇAPRAZ BAĞLANMASI}, key = {cite}, author = {ŞAFAK, Şerife and KARACA, Esra} }
APA ŞAFAK, Ş , KARACA, E . (2017). BİYOMEDİKAL UYGULAMALAR İÇİN POLİSAKKARİT ESASLI NANOLİFLİ YÜZEY ÜRETİMİ VE ÇAPRAZ BAĞLANMASI. Uludağ University Journal of The Faculty of Engineering, 22 (3), 127-144. DOI: 10.17482/uumfd.309657
MLA ŞAFAK, Ş , KARACA, E . "BİYOMEDİKAL UYGULAMALAR İÇİN POLİSAKKARİT ESASLI NANOLİFLİ YÜZEY ÜRETİMİ VE ÇAPRAZ BAĞLANMASI". Uludağ University Journal of The Faculty of Engineering 22 (2017): 127-144 <http://dergipark.gov.tr/uumfd/issue/31375/309657>
Chicago ŞAFAK, Ş , KARACA, E . "BİYOMEDİKAL UYGULAMALAR İÇİN POLİSAKKARİT ESASLI NANOLİFLİ YÜZEY ÜRETİMİ VE ÇAPRAZ BAĞLANMASI". Uludağ University Journal of The Faculty of Engineering 22 (2017): 127-144
RIS TY - JOUR T1 - BİYOMEDİKAL UYGULAMALAR İÇİN POLİSAKKARİT ESASLI NANOLİFLİ YÜZEY ÜRETİMİ VE ÇAPRAZ BAĞLANMASI AU - Şerife ŞAFAK , Esra KARACA Y1 - 2017 PY - 2017 N1 - doi: 10.17482/uumfd.309657 DO - 10.17482/uumfd.309657 T2 - Uludağ University Journal of The Faculty of Engineering JF - Journal JO - JOR SP - 127 EP - 144 VL - 22 IS - 3 SN - 2148-4147-2148-4155 M3 - doi: 10.17482/uumfd.309657 UR - http://dx.doi.org/10.17482/uumfd.309657 Y2 - 2017 ER -
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