Yıl 2018, Cilt 23, Sayı 1, Sayfalar 295 - 310 2018-04-24

EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ
Extracellular Matrix Structure and Tasks

İbrahim ÜÇGÜL [1] , Sultan ARAS [2] , Ufuk ELİBÜYÜK [3]

91 357

Ekstrasellüler matriks (ECM), memeli dokuları içindeki hücrelerin arasında bulunan ve onları destekleyen bir kompleks yapıdır. ECM içinde bulunduğu veya temas halindeki hücreler tarafından salgılanmaktadır. Ekstrasellüler matriks (ECM), geleneksel olarak glikoaminglikanlar ve fibröz proteinler olarak sınıflandırılırlar. Glikoaminglikanlarda kendi içlerinde sülfatlanmamış proteinler (Hyalüronik asit) ve sülfatlanmış proteinler (kondroitin sülfat, keratan sülfat I ve II, heparin, heparan sülfat ve dermatan sülfat) olmak üzere ikiye ayrılır. Fibröz proteinler ise yapısal proteinler (kollajen, elastin) ve yapıştırıcı (adhezyon) proteinler (Fibronektin, laminin, tenaskin, vitronektin, integrin) olarak sınıflandırılır. Yapılan bu çalışma ile hücrelerin yapısı ve hareketini etkileyen, hücre gelişme ve farklılaşmasını etkileyen, su ve mineral tutan, büyüme faktörünü etkileyen ekstrasellüler matris molekülünün yapısı ve bu yapıda bulunan proteinlerin görevlerinden bahsedilmiştir.

The extracellular matrix (ECM) is a complex structure located between and supporting cells within mammalian tissues. The ECM is secreted by cells in contact or contact. Extracellular matrix (ECM) is traditionally classified as glycosphingolipids and fibrous proteins. In glycosphingolipids, they are divided into two groups: non-sulfated proteins (hyaluronic acid) and sulfated proteins (chondroitin sulfate, keratin sulphate I and II, heparin, heparan sulfate and dermatan sulphate). Fibrous proteins are classified as structural proteins (collagen, elastin) and adhesion proteins (fibronectin, laminin, tenascin, vitronectin, integrin).This work deals with the structure of the extracellular matrix molecule affecting cell growth and differentiation, affecting cell growth and differentiation, water and minerals affecting the growth factor, and the proteins involved in this structure.

  • Akgün, I., Öğüt, T., (2002) Oral Glukozamin ve Kondroitin Sülfatın Osteoartrit Tedavideki Yeri. Türk Ortopedi ve Travmatoloji Birliği Derneği Dergisi, 1(2), 66-70.
  • Alovskaya, A., Alekseeva, T., Phillips, J.B., King, V., Brown, R., (2007) Fibronectin, collagen, fibrin-components of extracellular matrix for nerve regeneration. Topics in Tissue Engineering, 3, 1-26.
  • Ata, R., Antonescu, C.N., (2017) Integrins and Cell Metabolism: an Intimate Relationship Impacting Cancer. International Journal of Molecular Sciences, 18(189), 1-31. doi:10.3390/ijms18010189
  • Aviezer, D., Safran, M., Yayon, A., (1999) Heparin Differentially Regulates the Interaction of Fibroblast Growth Factor-4 with FGF Receptors 1 And 2. Biochemical and Biophysical Research Communications, 263(3), 621-626. doi: 10.1006/bbrc.1999.1434
  • Barczyk, M., Carracedo, S., Gullberg, D., 2010. Integrins. Cell Tissue Research, 339, 269-280. doi: 10.1007/s00441-009-0834-6.
  • Bayram, C., 2012. Hücre ve Doku Mühendisliği Araştırma Grubu. Nanoteknoloji ve Nanotıp Bilim Dergisi (N@nobülten), 18-27.
  • Bosman, F., ve Stamenkovic, I., (2003) Functional Structure and Composition of the Extracellular Matrix. Journal of Pathology, 200(4), 423-428. doi: 10.1002/path.1437
  • Campbell I.D., Humphries, M.J., (2011) Integrin Structure, Activation, and Interactions. Cold Spring Harbor Perspectives in Biology, 3, 1-14. doi: 10.1101/cshperspect.a004994
  • Cantor, J.O., Shteyngart, B, Cerreta, J.M., Lıu, M, Armand, G., Turıno, G.M., (2000) The Effect of Hyaluronan on Elastic Fiber Injury in Vitro and Elastaseinduced Airspace Enlargement in Vivo. Experimental Biology and Medicine, 225(1), 65– 71.
  • Chiquet-Ehrismann, R., (1990) What distinguishes tenascin from fibronectin? FASEB Journal, 4(9), 2598-2604.
  • Çavdar, Z., (2008) Kolon ve Rektum Kanserlerinde Endostatin’in Matriks Metalloproteinaz-2 Üzerine Gösterdiği Etkinin Araştırılması. Dokuz Eylül Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, Doktora Tezi, 144s., İzmir.
  • De Medeiros Matsushita M., Da Silva, L.F., Dos Santos, M.A., Fernezlian, S., Schrumpf, J.A., Roughley, P., Hiemstra, P.S., Saldiva, P.H., Mauad, T., Dolhnikoff, M., (2005) Airway Proteoglycans are Differentially Altered in Fatal Asthma. The Journal of Pathology, 207(1), 102-110. doi: 10.1002/path.1818
  • Debelle, L., Tamburro, A.M., (1999) Elastin: Molecular Description And Function. The International Journal of Biochemistry & Cell Biology, 31(2), 261-272. doi.org/10.1016/S1357-2725(98)00098-3
  • Frantz, C., Stewart, K.M., Weaver, V.M., (2010) The Extracellular Matrix at a Glance. Journal of Cell Science, 123(24), 4195-4200. doi: 10.1242/jcs.023820
  • Funderburgh, J.L., (2000) Keratan sulfate: structure, biosynthesis and function. Glycobiology, 10, 951-958. doi.org/10.1093/glycob/10.10.951
  • Funderburgh, J.L., (2002) Keratan Sulfate Biosynthesis. IUBMB Life, 54,187–194. doi: 10.1080/15216540214932
  • Gerdin, B., Hällgren, R., (1997) Dynamic Role of Hyaluronan (HYA) in Connective Tissue Activation and Inflammation. Journal of Internal Medicine, 242(1), 49–55. doi: 10.1046/j.1365-2796.1997.00173.x
  • Gill, S., Wight, T.N., Frevert, C.W., (2010) Proteoglycans: Key Regulators of Pulmonary Inflammation and the Innate Immune Response to Lung Infection. Anat Rec (Hoboken), 293(6), 968-981. doi: 10.1002/ar.21094
  • Green, W.F., Konnaris, K., Woolcock, A.J., 1993. Effect of Salbutamol, Fenoterol, and Sodium Cromoglycate on the Release of Heparin from Sensitized Human Lung Fragments Challenged with Dermatophagoides Pteronyssinus Allergen. American Journal of Respiratory Cell and Molecular Biology, 8(5), 518-521. doi: 10.1165/ajrcmb/8.5.518
  • Gullberg, D., (2003) I domains in integrins. vol 1. Landes Bioscience, Georgetown, Texas. pp 1–185. doi:10.1007/978-94-017-9153-3
  • Gümüşderelioğlu, M., Maviş, B., Karakeçili, A., Kahraman, A.S., Çakmak, S., Tığlı, S., Demirtaş, T., Aday, S., 2007. Doku Mühendisliğinde Nanoteknoloji. Bilim ve Teknik Dergisi, Yeni Ufuklara Eki, Ekim Sayısı.
  • Gürbüz, Y., Aydın, Ö., Almaç, A., (2006) Tenascin Expression Patterns Of Salivary Gland Tumors: An Immunhistochemical And Comparative Study. KBB-Forum Dergisi, 5(1), 35-40.
  • Handel, T.M., Johnson, Z., Crown, S.E., Lau, E.K., Proudfoot, A.E., (2005) Regulation of Protein Function by Glycosaminoglycans-as Exemplified by Chemokines. Annual Review of Biochemistry, 74, 385-410. doi: 10.1146/annurev.biochem.72.121801.161747
  • Hynes, R.O., (2002) Integrins: Bidirectional, Allosteric Signaling Machines. Cell, 110, 673-687. doi.org/10.1016/S0092-8674(02)00971-6
  • Järveläinen, H., Sainio, A., Koulu, M., Wight, T.N., Penttienen, R., (2009) Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy. Pharmacological Reviews, 61(2), 198-223. doi: 10.1124/pr.109.001289
  • Johansson, S., Svineng, G., Wennerberg, K., Armulik, A., Lohikangas, L., (1997) Fibronectin-Integrin Interactions. Frontiers in Bioscience 2, 126-146.
  • Kansu, E., 1996. Hücre Adhezyon Sistemi. Antibiyotik ve Kemoterapi Derneği Dergisi, 10(3), 314-317.
  • King, M.W., (2017) Extacellular Matrix. Erişim Adresi: https://themedicalbiochemistrypage.org/extracellularmatrix.php (Erişim Tarihi: 03.06.2017)
  • King, M.W., (2017) Glycosaminoglycans. Erişim Adresi: https://themedicalbiochemistrypage.org/glycans.php (Erişim Tarihi: 12.06.2017)
  • Kreuger, J., Matsumoto, T., Vanwildemeersch, M., Sasaki, T., Timpl, R., Claesson-Welsh, L., Spillmann, D., Lindahl, U., (2002) Role of Heparan Sulfate Domain Organization in Endostatin Inhibition of Endothelial Cell Function. The EMBO Journal, 21(23), 6303-6311. doi:10.1093/emboj/cdf638
  • Li, Y., Rahmanian, M., Widström, C., Lepperdinger, G., Frost, G.I., Heldin, P., (2000) Irradiation-Induced Expression of Hyaluronan (HA) Synthase 2 and Hyaluronidase 2 Genes in Rat Lung Tissue Accompanies Active Turnover of HA and Induction of Types I and III Collagen Gene Expression. American Journal of Respiratory Cell and Molecular Biology, 23(3), 411–418. doi: 10.1165/ajrcmb.23.3.4102
  • Lozzo, R.V., (1998) Matrix Proteoglycans: From Molecular Design to Cellular Function. Annual Review of Biochemistry, 67, 609-652. doi: 10.1146/annurev.biochem.67.1.609
  • Lozzo, R.V., Murdoch, A.D., (1996) Proteoglycans of the Extracellular Environment: Clues From the Gene and Protein Side Offer Novel Perspectives in Molecular Diversity and Function. The FASEB Journal, 10(5), 598-614.
  • Mercurio, A.M., Shaw, L.M., (1991) Laminin Binding Proteins. BioEssays, 13(9), 469-474. doi: 10.1002/bies.950130907
  • Miserocchi, G., Negrini, D., Passi, A., De Luca, G., (2001) Development of Lung Edema: Interstitial Fluid Dynamics and Molecular Structure. News in Physiological Sciences, 16, 66-71.
  • Mizumoto, S., Yamada, S., Sugahara, K., (2015) Molecular Interactions Between Chondroitin-Dermatan Sulfate And Growth Factors/Receptors/Matrix Proteins. Current Opinion in Structural Biology, 34, 35-42. doi: 10.1016/j.sbi.2015.06.004
  • Mizumoto S., Kosho, T., Yamada, S., Sugahara, K., (2017) Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders. Pharmaceuticals, 10(34), 1-15. doi: 10.3390/ph10020034
  • Monzon, M.E., Casalino-Matsuda, S.M., Forteza, R.M., (2006) Identification of Glycosaminoglycans in Human Airway Secretions. American Journal of Respiratory Cell and Molecular Biogoly, 34(2), 135-141. doi: 10.1165/rcmb.2005-0256OC
  • Neill, T., Schaefer, L., Iozzo, R.V., (2015) Decoding The Matrix: Instructive Roles of Proteoglycan Receptors. Biochemistry, 54, 4583–4598. doi: 10.1021/acs.biochem.5b00653
  • Onofri, F., (2016) Development of an Extracellular Matrix Hydrogel For Intestine Tissue Engineering. Università Degli Studi di Padova, Dipartimento di Ingegneria Industriale, Tesi di Laurea Masitrale, 75 p., Padova/Italy.
  • Ölmez, Ü., (2014) Kas-İskelet Sisteminin Yapı ve Fonksiyonları. Erişim Adresi: http://ichastaliklariromatoloji.medicine.ankara.edu.tr/files/2014/02/Kas-%C4%B0skelet-Sisteminin-Yap%C4%B1-ve-Fonksiyonlar%C4%B1.pdf (Erişim Tarihi: 20.06.2017)
  • Page, C.P., (1997) Proteoglycans: the "Teflon" of the Airways?. Thorax, 52(10), 924-925. doi.org/10.1136/thx.52.10.924
  • Peake, P.W., Greenstein, J.D., Pussell, B.A., Charlesworth, J.A., (1996) The Behaviour Human Vitronectin in Vivo: Effects of Complement Activation, Conformation and Phosphorylation. Clinical & Experimental Immunology, 106, 416-422. doi: 10.1046/j.1365-2249.1996.d01-833.x
  • Pelosi, P., Rocco, P.R.M., Negrini, D., Passi, A., (2007) The Extracellular Matrix of the Lung And its Role in Edema Formation. Annals of the Brazilian Academy of Sciences, 79(2), 285-297. doi.org/10.1590/S0001-37652007000200010
  • Pelosi, P., Severgnini, P., Rocco, P.R.M., (2007) The Extracellular Matrix of the Lung. Intersive Care Medicine, Spinger Press, 1040 s., Germany. doi: 10.1007/978-3-540-49433-1_29
  • Perdom, G., (2008) Laminin and the Cross Is There a Connection. Answers in Depth, 3, 83-84. Erişim Adresi: https://assets.answersingenesis.org/doc/articles/aid/v3/laminin-cross.pdf (Erişim Tarihi: 05.07.2017)
  • Pereira, I.O., (2011) Design and Construction of a Decellularization Cell. Faculdade de Engenharia, Mestrado Integrado em Bioengenharia, 87 p., Porto.
  • Rozario, T., DeSimone, D.W., (2010) The Extracellular Matrix in Development and Morphogenesis: A Dynamic View. Developmental Biology, 341(1), 126-140. doi: 10.1016/j.ydbio.2009.10.026
  • Ruoss, S.J., Gold, W.M., Caughey, G.H., (1991) Mast Cell Exocytosis: Evidence That Granule Proteoglycan Processing is not Coupled to Degranulation. Biochemical and Biophysical Research Communications, 179(1), 140-146. doi.org/10.1016/0006-291X(91)91346-E
  • Sasaki, M., Kleinman, H.K., Hubert, H., Deutzmann, R., Yamada, Y., (1988) Laminin, a Multidomain Protein. The Journal Of Biological Chemistry, 263(32), 16536-16544.
  • Scott, J.E., (1992) Supramolecular Organization of Extracellular Matrix Glycosaminoglycans, in Vitro and in The Tissues. The FASEB Journal, 6(9), 2639-2645.
  • Seyfeli, S., Üstünel, İ., Değer, N., Demir, R., (2001) Ekstrasellüler Matriks ve Bazı Kardiovasküler Hastalıklarla İlişkisi. Türkiye Klinikleri Kardiyoloji Dergisi, 14(6), 359-369.
  • Šimánek, V., Křen, V., Ulrichová, J., Gallo, J., (2005) The Efficacy of Glucosamine and Chondroitin Sulfate in the Treatment of Osteoarthritis: Are These Saccharides Drugs or Nutraceuticals. Biomedical Papers, 149(1), 51-56.
  • Sköld, C.M., Blaschke, E., Eklund, A., (1996) Transient Increases in Albumin and Hyaluronan in Bronchoalveolar Lavage Fluid After Quitting Smoking: Possible Signs of Reparative Mechanisms. Respiratory Medicine, 90(9), 523-529.
  • Souza-Fernandes A.B., Pelosı, P. Rocco, P.R.M., (2006) The Role of Glycosaminoglycans in Respiratory Disease. Critical Care, 10(6):237, 1-16. doi: 10.1186/cc5069
  • Şen, F., (2012) Matriks Metalloproteinaz-3 (MMP-3) ve Matriks Metalloproteinaz-9 (MMP-9) Gen Polimorfizminin Akut Miyokard İnfarktüsüne Olası Etkileri. Mersin Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Uzmanlık Tezi, 104 s., Mersin.
  • Takagaki, K., Munakata, H., Kakizaki, I., Iwafune, M., Itabashi, T., Endo, M., (2002) Domain Structure of Chondroitin Sulfate E Octasaccharides Binding to Type V Collagen. The Journal of Biological Chemistry, 277(11), 8882-8889. doi: 10.1074/jbc.M106479200
  • Tammi, M.I., Day, A.J., Turley, E.A., (2002) Hyaluronan and Homeostasis: A Balancing Act. The Journal of Biological Chemistry, 277, 4581-4584. doi: 10.1074/jbc.R100037200
  • Toole, B.P., (1990) Hyaluronan and its Binding Proteins, the Hyaladherins. Current Opinion in Cell Biology, 2(5), 839-844. doi.org/10.1016/0955-0674(90)90081-O
  • Trowbridge, J.M., Gallo, R.L., (2002) Dermatan Sulfate: New Functions From an Old Glycosaminoglycan. Glycobiology, 12, 117R–125R. doi.org/10.1093/glycob/cwf066
  • Tuan, R.S., (2004) Biology of Developmental and Regenerative Skeletogenesis. Clinical Orthopaedics & Related Research, 427, 105-117. doi: 10.1097/01.blo.0000143560.41767.ee
  • Turino, G.M., Cantor, J.O.,(2003) Hyaluronan in Respiratory Injury and Repair. American Journal of Respiratory and Critical Care Medicine, 167(9), 1169-1175. doi: 10.1164/rccm.200205-449PP
  • Turnova, S., Woods, A., Couchman, J.R., (2000) Heparan Sulfate Proteoglycans on the Cell Surface: Versatile Coordinators of Cellular Functions. The International Journal of Biochemistry & Cell Biology, 32(3), 269-288. doi.org/10.1016/S1357-2725(99)00116-8
  • Tyrrell, D.J., (1995) Therapeutic Uses of Heparin Beyond its Traditional Role as an Anticoagulant. Trends in Pharmacological Sciences, 16(6), 198-204. doi.org/10.1016/S0165-6147(00)89022-7
  • Ulutin, T., (2015) Ekstraselüler Matris Ders Notları. Erişim Adresi: http://194.27.141.99/dosya-depo/ders-notlari/turgut-ulutin/Ekstraseluler_Matriks.pdf (Erişim Tarihi: 12.08.2015)
  • Uslu, B., Arbak, S., 2010. Doku Mühendisliğinde Kitosanın Kullanım Alanları. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 1(3), 128-135.
  • Wilusz, R.E., Sanchez-Adams, J., Guilak, F., (2014) The Structure and Function of the Pericellular Matrix of Articular Cartilage. Journal of the International Society for Matrix Biology, 39, 25-32. doi: 10.1016/j.matbio.2014.08.009
  • Wong, E.V., (2009) Cells: Molecules and Mechnisms. Axolotl Academic Publishing Company, 271 p., Louisville, Kentucky/USA.
  • Xu, J., Mosher, D., (2011) Fibronectin and Other Adhesive Glycoproteins. The Extracellular Matrix: an Overview, Biology of Extracellular Matrix, Mecham, R. (Ed), 426, Springer-Verlag Berlin Heidelberg.
  • Yiğit, A., Yiğit, B., Koşar, Aslan, P., Savaş, H.B., Korkmaz, M., 2016. Doku Mühendisliğinde Deselülerizasyon Metotları ile Ekstraselüler Matriks (ECM) Eldesi ve Tıbbi Tedavide Uygulama Alanları. Kimya ve Sanayi Dergisi, 2(6), 29-43.
  • Yurchenco P.D., Schittny, J.C., (1990) Molecular Architecture of Basement Membranes. The FASEB Journal, 4(6), 1577-1590.
  • Zhao, J., Sime, P.J., Bringas, P., Gauldie, J., Warbuton, D., (1999) Adenovirus-Mediated Decorin Gene Transfer Prevents TGF-β-Induced Inhibition of Lung Morphogenesis. American Journal of Physiology, 277(2), 412-422.
  • Zhu, J.K., Damsz, B., Kononowicz, A.K., Bressan, R.A., Hasegawa, P.M., (1994) A Higher Plant Extracellular Vitronectin-like Adhesion Protein Is Related to the Translational Elongation Factor-Iα. American Society of Plant Physiologists, 6, 393-404. doi: 10.1105/tpc.6.3.393
Birincil Dil tr
Konular Mühendislik ve Temel Bilimler
Dergi Bölümü Derleme Makaleler
Yazarlar

Yazar: İbrahim ÜÇGÜL
Kurum: Süleyman Demirel Üniversitesi
Ülke: Turkey


Yazar: Sultan ARAS
Ülke: Turkey


Yazar: Ufuk ELİBÜYÜK
Ülke: Turkey


Bibtex @derleme { uumfd327376, journal = {Uludağ University Journal of The Faculty of Engineering}, issn = {2148-4147}, eissn = {2148-4155}, address = {Uludağ Üniversitesi}, year = {2018}, volume = {23}, pages = {295 - 310}, doi = {10.17482/uumfd.327376}, title = {EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ}, key = {cite}, author = {ÜÇGÜL, İbrahim and ELİBÜYÜK, Ufuk and ARAS, Sultan} }
APA ÜÇGÜL, İ , ARAS, S , ELİBÜYÜK, U . (2018). EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ. Uludağ University Journal of The Faculty of Engineering, 23 (1), 295-310. DOI: 10.17482/uumfd.327376
MLA ÜÇGÜL, İ , ARAS, S , ELİBÜYÜK, U . "EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ". Uludağ University Journal of The Faculty of Engineering 23 (2018): 295-310 <http://dergipark.gov.tr/uumfd/issue/36268/327376>
Chicago ÜÇGÜL, İ , ARAS, S , ELİBÜYÜK, U . "EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ". Uludağ University Journal of The Faculty of Engineering 23 (2018): 295-310
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EndNote %0 Uludağ University Journal of The Faculty of Engineering EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ %A İbrahim ÜÇGÜL , Sultan ARAS , Ufuk ELİBÜYÜK %T EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ %D 2018 %J Uludağ University Journal of The Faculty of Engineering %P 2148-4147-2148-4155 %V 23 %N 1 %R doi: 10.17482/uumfd.327376 %U 10.17482/uumfd.327376
ISNAD ÜÇGÜL, İbrahim , ARAS, Sultan , ELİBÜYÜK, Ufuk . "EKSTRASELÜLER MATRİS YAPISI VE GÖREVLERİ". Uludağ University Journal of The Faculty of Engineering 23 / 1 (Nisan 2018): 295-310. http://dx.doi.org/10.17482/uumfd.327376